M. Del Sette 1, S. Ricci 2, E. Giorli 1, M. Cotroneo 3
1 Neurology Unit – La Spezia, Italy,
2 Stroke Unit – Città di Castello, Italy,
3 Department of Neurology University of Messina – Messina, Italy

Objective: sonothrombolysis (ST) can increase the penetration of circulating tPA into the thrombus, promote the breaking and cleaving of the fibrin polymers, and improve the binding affinity of tPA to fibrin. A recent Cochrane Review of all the randomized studies published on ST reported significantly more recanalizations and better clinical outcome, with no effect on mortality. The ultras study is a pilot study aiming at defining efficacy of ST in acute ischemic stroke.

S. Andonova-Atanasova 1, F. Kirov 1, M. Petkova 1, P. Kirilova 1, E. Kalevska 1, V. Argirova 1, Zv. Zvetkov 1, M. Novakova 2, R. Georgiev 2, V. Georgieva 3
1 Department of Neurology, Second Clinic of Neurology,
2 Department of Radiology, 3Centre of Emergency, University Hospital St. Marina – Varna, Bulgaria

Objective: The aim of the present study is to describe the results and the problems in evaluation of the thrombolytic therapy for management of acute ischemic stroke in the Second clinic of Neurology with Intensive Neurology Care Unit .

M. De Lima Oliveira, R. Nogueira, K. Andrade Norremose, A. Maria Negrao Esteves, F. Iuji Yamamoto, E. Faria Evaristo, M. Jacobsen Teixeira, E. Bor-Seng-Shu
Department of Neurology, University Hospital, University of São Paulo – São Paulo, Brazil

Objective: It is supposed that Transcranial Doppler ultrasonography (TCD) during thrombolysis may help to expose thrombi to tissue plasminogen acPvator (t-PA). The aim of this study is to determine if TCD can safely enhance the thrombolyPc acPvity of t-PA.

Material and Methods: Patients with acute ischemic stroke which fufill current criteria to intravenous t-PA treatment were randomly assigned to receive continuous 2 MHz TCD (the target group) or placebo (the control group). In follow up analysis, outcomes are defined as good (as indicated by a score of 0 to 2 on the modified Rankin scale) or favorable (scores of 0 to 1 on modified Rankin Scale).

I. Petrov, M. Klissurski, S. Sirakov, B. Zehirov, A. Mihaylov, D. Petkova, Ts. Pramatarova, T. Kmetski, G. Georgieva-Kozarova, L. Penev, L. Grozdinski
City Clinic Cardiology Center MPHAC – Sofia, Bulgaria

Objective: To report the clinical, radiological, and haemodynamic data of three patients with AIS who underwent IAT.

Material and Methods: Two men and one woman, mean age of 61.6, two with MCA occlusion and one with posterior AIS, were treated. Clinical outcome was assessed according to NIHSS and mRS on day 1, 30 and 90. Neuroimaging included non-contrast CT or MRI, diffusion and angio MRI. All patients underwent cerebral angiography and met criteria for endovascular TL. Transcranial duplex scanning was used for haemodynamic assessment of the occlusion and recanalization. Actiyse was infused supraselectively via microcatheter in a mean dose of 38.3 mg. TICI score was documented at the end of the procedure. Post-procedural I.V. 24 h heparin infusion was given to one patient with poor TICI result.