M. De Lima Oliveira 1, J. Luiz Pedroso 2, P. Braga Neto 3, M. Ferreira Machado 4, R. Nogueira 5, O. Graziani Povoas Barsottin 6, E. Bor-Seng-Shu 7
1 Department of Neurolgy, University Hospital of São Paulo,
2 Department of Neurology, Medical Faculty, Federal University of São Paulo,
3 Hospital Israelita Albert Einstein – São Paulo, Brazil

Objective: Several studies have demonstrated increased substantia nigra (SN) in Parkinson's disease (PD), and Machado Joseph disease (MJD). Pathological substrate of PD is characterized by dopaminergic nigrostriatal cell loss, also found in MJD. Also, SN hiperechogenicity might be associated with nigrostriatal disfunction in PD, when comparing dopamine transport binding with SN echogenicity. The present study aimed to correlate the SN echogenicity size and striatal dopamine transporter density in MJD patients.

Material and Methods: We performed TCS in 30 subjects and spect with (99mm TC) - TRODAT-1 in 18 subjects with MJD. Fifteen healthy subjects matched for age and gender formed control group. TCS and (99mm TC) -TRODAT-1 SPECT findings both MJD patients and control group subjects were compared.

Results: There were no differences regarding age (p=0.358) or gender (p=0,566) between groups (MJD versus control group). Mean DAT binding potentials and SN echogenicity were significantly different between groups. There was significant negative correlation with regard to the SN echogenic size and the ipsilateral striatal TRODAT 1 uptake: the higher SN echogenicity, the lower DAT uptake in the isilateral cerebral hemisphere.

Discussion: Increase in SN echogenic size likely correlates with presynaptic dopaminergic nigrostriatal in MJD, suggesting a concurrent in vivo pathophysiological mechanism.

Key words: brain ultrasound Dupplex, Machado Joseph disease, substantia nigra echogenicity, TRODAT.

Your are currently browsing this site with Internet Explorer 6 (IE6).

Your current web browser must be updated to version 7 of Internet Explorer (IE7) to take advantage of all of template's capabilities.

Why should I upgrade to Internet Explorer 7? Microsoft has redesigned Internet Explorer from the ground up, with better security, new capabilities, and a whole new interface. Many changes resulted from the feedback of millions of users who tested prerelease versions of the new browser. The most compelling reason to upgrade is the improved security. The Internet of today is not the Internet of five years ago. There are dangers that simply didn't exist back in 2001, when Internet Explorer 6 was released to the world. Internet Explorer 7 makes surfing the web fundamentally safer by offering greater protection against viruses, spyware, and other online risks.

Get free downloads for Internet Explorer 7, including recommended updates as they become available. To download Internet Explorer 7 in the language of your choice, please visit the Internet Explorer 7 worldwide page.